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Ultimately, the optimized lead molecule MEDI4166 displayed robust glucose-lowering effects that persisted for up to 14 days following a single dose in DIO mice, whereas blood glucose levels approached baseline levels for the non-stabilized control molecule (Fig
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Diabetes 2026, 75 DOI: 10.2337/db26-2637-p.Peer-Reviewed Original ResearchConceptsII trialefficacy of high dosephase 3 registration trialsefficacy of dosesTEAE-related discontinuationsweight-related comorbidityphase 2 trial resultsbody-weight reductionbody weight lossAbbVie Inc.dose armmean BMIOnce-DailyGLP-1RAhigh dosesinterim analysisdoseobesityweight lossplaceboweeksefficacytrial durationre-randomizedAmgen Inc
